Immunopathologic changes in rheumatoid arthritis synovium
نویسندگان
چکیده
منابع مشابه
The Synovium in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting multiple joints. The synovium is the primary site of the inflammatory process, which if untreated leads to irreversible damage to the adjacent cartilage and bone. It is now well established that autoantibodies that are characteristic of RA, including rheumatoid factor (RF) and anti-citrulluninated protein antibodies (ACPA), are...
متن کاملRheumatoid arthritis synovium contains plasmacytoid dendritic cells
We have previously described enrichment of antigen-presenting HLA-DR+ nuclear RelB+ dendritic cells (DCs) in rheumatoid arthritis (RA) synovium. CD123+HLA-DR+ plasmacytoid DCs (pDCs) and their precursors have been identified in human peripheral blood (PB), lymphoid tissue, and some inflamed tissues. We hypothesized recruitment of pDCs into the inflamed RA synovial environment and their contribu...
متن کاملCorrection: Cells of the synovium in rheumatoid arthritis. Chondrocytes
After publication of our recent article [1], we noticed an error in the third sentence of the third paragraph of the section entitled, 'Joint inflammation and cartilage remodeling in RA'. This sentence should read: ADAMTS-5 is expressed constitutively, whereas ADAMTS-4 is more prominently regulated by inflammatory cytokines.
متن کاملCells of the synovium in rheumatoid arthritis. Dendritic cells
Dendritic cells are the major antigen-presenting and antigen-priming cells of the immune system. We review the antigen-presenting and proinflammatory roles played by dendritic cells in the initiation of rheumatoid arthritis (RA) and atherosclerosis, which complicates RA. Various signals that promote the activation of NF-kappaB and the secretion of TNF and IL-1 drive the maturation of dendritic ...
متن کاملCells of the synovium in rheumatoid arthritis. Osteoclasts
Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells. Numerous osteoclasts are found within the synovial tissue at sites adjacent to bone, creating resorption pits and local bone destruction. They are equipped with specific enzymes and a proton pump that enable them to degrade bone matrix and solubilize calcium, respectively. The synovial tissue ...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1966
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780090202